Health Professionals

The California Dried Plum Board sponsors nutrition and medical research that supports the role of dried plums in a balanced and health-promoting diet.

Dried Plums (prunes) Reduce Atherosclerosis Lesion Area in Apolipoprotein E-Deficient Mice

10-31-2008

British Journal of Nutrition 2008 Sept. 2:1-7 E-pub ahead of print.

Gallaher, C.M. and Gallaher, D.D


The apoE-deficient mouse, which develops atherosclerotic lesions rapidly when fed cholesterol, was used to determine the ability of dried plums at different dose levels to reduce atherosclerosis.  Arterial trees were dissected, stained to visualize lesions, and lesion area was quantitated by imaging software.  Percentage arterial tree atherosclerotic lesion area was significantly lower in the low dose dried plum diet with a trend in difference with the higher dried plum diet.  These results suggest that consuming dried plums may help slow the development of atherosclerosis.  The study also reported on other measures of oxidative stress and inflammation

Dried Plum Polyphenols Attenuate the Detrimental Effects of TNF-a on Osteoblast Function Coincident with Up-regulation of Runx2, Osterix and IGF-1

07-02-2008

Journal of Nutritional Biochemistry DOI:10.1016/j.jnutbio.2007.11.012 Published online ahead of print May 20, 2008.
Bu, S.Y., Hunt, T.S., and Smith, B.J.

This cell culture study investigated how dried plum polyphenols and different concentrations ((0, 2.5, 5, 10 and 20 μg/ml) might influence osteoblast activity and mineralized nodule formation under normal and inflammatory conditions. Polyphenol doses of 5, 10 and 20 μg/ml enhanced the production of compounds linked to bone formation and countered the detrimental effects of TNF-a addition

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